主 题： Integrated Hybrid Lab-on-Chips for Human Disease Studies
内容简介：The field of drug discovery is in urgent need for more relevant biological models and advanced technologies to improve the process of finding therapeutics for human diseases. Two of the most promising disease models are (i) small whole organisms such as C. elegans, D. melanogaster and D. rerio, and (ii) three-dimensional organs, organelles and tissues. Each of these models have their own advantages and disadvantages that will be discussed during the talk. However, one commonality between them is the need for automated sample processing and screening technologies to enhance the quality and throughput of screening. Microfluidics has been among the top technologies that hold a great potential to address this gap in the drug discovery industry. In this talk I will introduce you to the latest research in the field of organisms- and organs-on-a-chip for drug discovery and fundamental disease studies.
Dr. Pouya Rezai is an emerging researcher in the area of microfluidics and Lab-on-Chips (LoC). He received his Master of Science in Electrical Engineering from Chalmers University of Technology in 2008 and his PhD in Mechanical Engineering from McMaster University in 2012. Dr. Rezai was an NSERC Visiting Fellow at Public Health Agency of Canada before joining York University in July 2013 as an Assistant Professor. He serves as the founding Graduate Program Director of the Department of Mechanical Engineering at York University and the Associate Editor of the Canadian Society for Mechanical Engineering (CSME) bulletin. He is also an Associate Member of the Graduate Program in Biology at York University.
Dr. Rezai’s research interest is to advance micromachining and microfabrication technologies to develop LoC devices for studying interactions between micro-particles, small biological substances and fluids in microenvironments with applications in biology and medicine. His research group has developed (i) LoC for quantitative investigation of neurobehavioral responses of disease model organisms (D. melanogaster, C. elegans, and D. rerio) to electric, acoustic, and chemical cues; (ii) microfluidic platforms for multiplexed sorting of microorganisms and microparticles in fluidic samples; and (iii) micro-electro-mechanical sensors and actuators to exploit the advantages of composite and functional polymers and carbon nano-structures in miniaturized devices.